| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
hsa‐miR‐627‐3p, hsa‐miR‐329‐5p, hsa‐miR‐25‐3p, hsa‐miR‐766‐5p, hsa‐miR‐143‐5p |
| Biological function: |
Potential roles in the incidence and development of MDS (predicted). |
| Molecular mechanism: |
Predicted ceRNA mechanism via circRNA-miRNA-mRNA network. |
| Biological pathway or process: |
ceRNA regulation (other); cell cycle (other); p53 signaling (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; divergent primers PCR; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Valuable for diagnosis and prognosis of MDS; ROC AUC 0.7121; high expression associated with poorer overall survival. |
| Description: |
hsa_circRNA_100352 is up-regulated in bone marrow from MDS patients and shows diagnostic value by ROC analysis. Higher expression is associated with poorer overall survival, and bioinformatic predictions suggest it may act in a circRNA-miRNA-mRNA ceRNA network relevant to MDS development. |
| Confidence score: |
0.7151 |