circRNA basic information
circBase ID: hsa_circ_0002782
Name: hsa_circ_SLC39A8
Synonym: CircSLC39A8
Host Gene: hsa-miR-185-5p
 
 
 
Disease basic information
DO ID:
 2394
DO name: ovarian cancer
Disease details: ovarian cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human ovarian cancer cell lines (SKOV3, A2780)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: BMF
Associated microRNA: hsa-miR-185-5p
Biological function: Biologically, circSLC39A8 knockdown promoted PTX resistance in vitro and in vivo, while circSLC39A8 overexpression showed the opposite effect.
Molecular mechanism: circSLC39A8/hsa-miR-185-5p/BMF axis, miRNA sponge
Survival: better
Supported No.:
 1
Description:

Our findings demonstrate that circSLC39A8 can promote PTX sensitivity by regulating the miR-185_5p/BMF axis.

Other information
Title:

CircSLC39A8 attenuates paclitaxel resistance in ovarian cancer by regulating the miR_185_5p/BMF axis

Journal: Transl Oncol
Published: 2023/7/25
PubMed ID: 37499410