| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Serum circ_0001955 acts as a clinical biomarker for PTC diagnosis and for predicting WBS-positive recurrence/metastasis risk after radical thyroidectomy and iodine-131 therapy; its expression is associated with TNM stage. |
| Molecular mechanism: |
The molecular mechanism of circ_0001955 in PTC was not determined in this study. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Cohort Study; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Serum circ_0001955 has diagnostic value for PTC and may help predict recurrence/WBS-positive status after radical thyroidectomy and iodine-131 therapy, especially in combination with Tg and TgAb. |
| Description: |
This study identifies serum hsa_circ_0001955/circ_0001955 as up-regulated in PTC patients compared with multinodular goiter patients and healthy controls. Elevated serum circ_0001955 is associated with TNM stage and WBS-positive status after iodine-131 therapy, and it may serve as a diagnostic and recurrence-prediction biomarker, particularly when combined with Tg and TgAb. The study did not define a molecular regulatory mechanism for circ_0001955 in PTC. |
| Confidence score: |
0.5121 |