circRNA basic information
circBase ID: hsa_circ_0001438
Name: -
Synonym: circular RNA 0001438
Host Gene: -
Genomic location(hg19): chr4:128995614-128999117:+
Genomic location(hg38): chr4:128074459-128077962:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

gastric cancer tissues; matched precancerous tissues
Cell lines:

AGS; HGC27; MKN45; SNU165; GES-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: miR-1290
Biological function: Overexpression of circ_0001438 inhibited proliferation, migration, invasion, metastasis, and gastric cancer cell activity.
Molecular mechanism: circ_0001438 negatively regulates gastric cancer cell activity by sponging and downregulating miR-1290.
Biological pathway or process:

ceRNA regulation (other); proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Cohort Study; Survival Analysis
Clinical significance:

circ_0001438 expression was associated with lymph node metastases, tumor size, TNM stage, and prognosis; low circ_0001438 expression predicts poor prognosis of gastric cancer patients.
Description:

circ_0001438 is downregulated in gastric cancer tissues and cells. Its overexpression suppresses gastric cancer cell proliferation, migration, invasion, and metastasis, at least partly by sponging/downregulating miR-1290. Clinically, low circ_0001438 expression is associated with larger tumor size, TNM stage, lymph node metastasis, and poorer 5-year survival.
Confidence score:

0.7081
Other information
Title:

Expression and Significance of the Circular RNA circ_0001438 in the Development of Gastric Cancer.

Journal: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer
Published: 2025
PubMed ID: 39462446
Study type:

combined biological and clinical study
Data availability: -
Code availability: -