| Expression pattern: |
UP |
| Associated gene: |
ESRP1, IGF2BP2, DKK3 mRNA, AHR mRNA |
| Associated microRNA: |
miR-3692-5p, miR-6875-3p, miR-767-5p |
| Biological function: |
circUBAP2 maintains epithelial plasticity, supports ovarian cancer cell proliferation, restricts migration and invasion in vitro, and aids peritoneal dissemination through ESRP1-induced RNA cyclization. |
| Molecular mechanism: |
ESRP1 binds GGU sequences in adjacent introns to trigger circUBAP2 cyclization; circUBAP2 interacts with IGF2BP2 to stabilize DKK3 and AHR mRNAs, preserving epithelial traits and modulating epithelial plasticity. |
| Biological pathway or process: |
proliferation (promotes); migration (inhibits); invasion (inhibits); metastasis (promotes); EMT (inhibits); mRNA stability (promotes); other pathway/process (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RIP (RNA Immunoprecipitation); Bioinformatics Analysis; Transfection; EdU Staining; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
Potential therapeutic target for curbing metastatic dissemination and improving the prognosis of ovarian cancer patients. |
| Description: |
circUBAP2 is an ESRP1-induced circular RNA in ovarian cancer cells. It promotes proliferation and epithelial plasticity while restricting migration and invasion in vitro, and mechanistically works with IGF2BP2 to stabilize DKK3 and AHR mRNAs, supporting peritoneal dissemination. |
| Confidence score: |
0.7872 |