| Expression pattern: |
UP |
| Associated gene: |
RAB3B, Ago2 |
| Associated microRNA: |
miR-155-5p |
| Biological function: |
Promotes cervical cancer cell proliferation; associated with large tumor size and differentiation of CC tissues. |
| Molecular mechanism: |
circ_0000337 acts as a ceRNA by sponging miR-155-5p, thereby upregulating RAB3B expression. |
| Biological pathway or process: |
proliferation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot |
| Clinical significance: |
High circ_0000337 expression is correlated with large tumor size and high differentiation of CC tissues; circ_0000337 is highlighted as a promising potential novel target for CC treatment. |
| Description: |
circ_0000337 is upregulated in cervical cancer tissues and cell lines. It promotes CC cell proliferation by acting as a ceRNA for miR-155-5p and increasing RAB3B expression, and its high expression is associated with larger tumor size and differentiation. |
| Confidence score: |
0.6903 |