| Expression pattern: |
UN |
| Associated gene: |
BIRC5, PIK3CB, hnRNPC, hnRNPA1 |
| Associated microRNA: |
miR-149, miR-542, hsa-miR-149-5p, hsa-miR-542-5p |
| Biological function: |
circMMP9 is proposed as an oncogenic circRNA and potential therapeutic target in glioblastoma; it may enhance proliferation and suppress apoptosis by regulating miR-149-5p/miR-542-5p and BIRC5, and it may interact with hnRNPC/hnRNPA1 to contribute to cancer progression. |
| Molecular mechanism: |
circMMP9 may act through a ceRNA-like mechanism by sponging miR-149-5p and miR-542-5p, thereby affecting BIRC5 expression; it also directly interacts with hnRNPC and hnRNPA1 RNA-binding proteins and may transport them. |
| Biological pathway or process: |
apoptosis (inhibits); proliferation (promotes); ceRNA regulation (other); PI3K/AKT (other); AMPK (other) |
| Detected method: |
M
|
| Validation methods: |
Bioinformatics Analysis; Survival Analysis; Microarray |
| Clinical significance: |
circMMP9 is proposed as a promising therapeutic target for GBM and may have potential therapeutic significance based on human data analysis. |
| Description: |
This study proposes circMMP9/hsa_circ_0001162 as an oncogenic circRNA and potential therapeutic target in glioblastoma. Through bioinformatic prediction and human data analysis, circMMP9 is suggested to sponge miR-149-5p and miR-542-5p, rescue BIRC5 expression, promote proliferation, and suppress apoptosis. It is also predicted to interact with hnRNPC and hnRNPA1 RNA-binding proteins, potentially contributing to GBM progression. |
| Confidence score: |
0.348 |