circRNA basic information
circBase ID: hsa_circ_0017636
Name: hsa_circ_SFMBT2
Synonym: circSFMBT2-OA
Host Gene: -
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: cell line
Sample type details: CHON-001 chondrocytes
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: NLRP3
Associated microRNA: -
Biological function: circSFMBT2-OA overexpression accelerated cell proliferation, and suppressed cell apoptosis, pro-inflammatory cytokines production, matrix-degrading enzymes expression, and ECM degradation in CHON-001 cells.
Molecular mechanism: circSFMBT2-OA inhibited LPS-induced NF-¦ĘB/NOD-like receptor family pyrin domain containing protein 3 (NLRP3) inflammasome activation in CHON-001 cells.
Survival: -
Supported No.:
 1
Description:

These data reveal a vital effect of a novel circSFMBT2-OA on repressing OA progression and provide a promising target to treat OA.
Other information
Title:

CircSFMBT2-OA alleviates chondrocyte apoptosis and extracellular matrix degradation through repressing NF-kappaB/NLRP3 inflammasome activation.

Journal: Heliyon
Published: 2023/7/13
PubMed ID: 37441407