| Expression pattern: |
UP |
| Associated gene: |
NRP1 |
| Associated microRNA: |
miR-217 |
| Biological function: |
Facilitates gastric cancer progression, oxaliplatin resistance, proliferation, migration, invasion, and tumor growth; circ_0006089 knockdown represses these malignant phenotypes and enhances OXA sensitivity. |
| Molecular mechanism: |
circ_0006089 functions as a ceRNA sponge for miR-217 and upregulates NRP1 expression, thereby promoting gastric cancer progression and oxaliplatin resistance. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); drug resistance (promotes); chemoresistance (promotes); ceRNA regulation (other); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; MTT; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
High circ_0006089 expression is related to poorer prognosis and associated with histology grade, TNM stage and lymph node metastasis in GC patients; it is proposed as a promising biomarker for GC therapy. |
| Description: |
circ_0006089 is up-regulated in oxaliplatin-resistant gastric cancer tissues and cells. It promotes GC progression, tumor growth, migration, invasion, and oxaliplatin resistance by sponging miR-217 and increasing NRP1 expression. High circ_0006089 expression is associated with poorer prognosis and adverse clinicopathological features. |
| Confidence score: |
0.7548 |