| Expression pattern: |
DN |
| Associated gene: |
PTEN |
| Associated microRNA: |
miR-182-5p |
| Biological function: |
Overexpression of circ_0008193 suppresses proliferation, migration, and invasion of cervical cancer cells. |
| Molecular mechanism: |
ceRNA mechanism in which circ_0008193 targets miR-182-5p and regulates downstream PTEN expression. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (inhibits); migration (inhibits); invasion (inhibits); p53 signaling (other); PI3K/AKT (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay |
| Clinical significance: |
May facilitate individualized treatment and provide targets for cervical cancer treatment. |
| Description: |
hsa_circ_0008193/circ_0008193 is down-regulated in cervical cancer cells and acts as a suppressive circRNA in this study. Mechanistically, it functions in a circ_0008193-miR-182-5p-PTEN ceRNA axis, with circ_0008193 overexpression inhibiting cervical cancer cell proliferation, migration, and invasion. |
| Confidence score: |
0.5804 |