| Expression pattern: |
UP |
| Associated gene: |
ARL2, Ago2 |
| Associated microRNA: |
miR-142-3p |
| Biological function: |
promotes cervical cancer cell proliferation, migration and invasion; facilitates tumor growth; knockdown induces cell cycle arrest |
| Molecular mechanism: |
ceRNA mechanism: circ_0084927 sponges miR-142-3p to upregulate ARL2 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); cell cycle (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Cell Cycle Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation; Survival Analysis |
| Clinical significance: |
high circ_0084927 expression was associated with a relatively lower survival rate |
| Description: |
circ_0084927 is up-regulated in cervical cancer tissues/cells and promotes malignant phenotypes (proliferation, cell-cycle progression, migration/invasion) and xenograft tumor growth. Mechanistically, it acts as a ceRNA to sponge miR-142-3p, thereby de-repressing/upregulating ARL2. |
| Confidence score: |
0.8001 |