| Expression pattern: |
UP |
| Associated gene: |
NAMPT |
| Associated microRNA: |
miR-515-5p |
| Biological function: |
circSEC24A promotes IL-1beta-induced chondrocyte injury, including reduced cell viability, oxidative stress, apoptosis, ECM degradation, and inflammation; circSEC24A knockdown protects CHON-001 cells against IL-1beta-mediated damage. |
| Molecular mechanism: |
circSEC24A functions as a ceRNA by sponging miR-515-5p to regulate NAMPT expression in IL-1beta-treated chondrocytes. |
| Biological pathway or process: |
ceRNA regulation (other); apoptosis (promotes); inflammation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Western Blot; ELISA; Luciferase Reporter Assay; RNA Pull-Down; Bioinformatics Analysis |
| Clinical significance: |
circSEC24A expression was associated with body mass index (BMI) and alcohol consumption; circSEC24A may provide a feasible treatment option for chondroprotection of OA sufferers. |
| Description: |
circSEC24A is up-regulated in OA cartilage tissues and IL-1beta-treated CHON-001 chondrocytes. It promotes IL-1beta-induced chondrocyte injury by enhancing oxidative stress, apoptosis, ECM degradation, and inflammation while reducing cell viability. Mechanistically, circSEC24A acts as a miR-515-5p sponge to increase NAMPT expression, forming a circSEC24A/miR-515-5p/NAMPT ceRNA axis. |
| Confidence score: |
0.8111 |