| Expression pattern: |
UP |
| Associated gene: |
SOX5 |
| Associated microRNA: |
miR-1200 |
| Biological function: |
Promotes gastric cancer cell proliferation, cell cycle progression, glycolysis, and tumor growth; inhibits apoptosis. |
| Molecular mechanism: |
circFLNA functions as a miR-1200 sponge to indirectly upregulate SOX5 expression and promote gastric cancer progression. |
| Biological pathway or process: |
proliferation (promotes); glycolysis (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; Cell Cycle Assay; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; In Vivo Animal Model; IHC (Immunohistochemistry); Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circFLNA expression was associated with lower overall survival rate in GC patients and circFLNA may be a potential target for GC therapy. |
| Description: |
circFLNA is upregulated in gastric cancer tissues and cell lines, and high expression is associated with poorer overall survival. Functionally, circFLNA promotes GC cell proliferation, glycolysis and in vivo tumor growth while suppressing apoptosis. Mechanistically, circFLNA acts as a sponge for miR-1200 to increase SOX5 expression, forming a circFLNA/miR-1200/SOX5 regulatory axis. |
| Confidence score: |
0.7793 |