circRNA basic information
circBase ID: hsa_circ_0083964
Name: hsa_circ_ASH2L
Synonym: circASH2L
Host Gene: ASH2L
Genomic location(hg19): chr8:37985808-37986469:+
Genomic location(hg38): chr8:38128290-38128951:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008383
MONDO name: rheumatoid arthritis
Disease details: rheumatoid arthritis
Disease DO ID:
 7148
Disease MeSH ID:
 D001172
Disease NCIt ID:
 C2884
Disease ICD11 ID:
 576319925
Disease OMIM ID:
 180300
Species: Human
Species details: Homo sapiens
Tissue specimen:

synovial tissues
Cell lines:

RA-FLSs / N-FLSs
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: HIPK2
Associated microRNA: miR-129-5p
Biological function: Promotes RA-FLS growth (proliferation, cell cycle progression), migration, invasion, and inflammation; inhibits apoptosis.
Molecular mechanism: Acts as a miRNA sponge/ceRNA by targeting miR-129-5p to regulate HIPK2 expression.
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); cell cycle (promotes); migration (promotes); invasion (promotes); inflammation (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Clinical Sample Validation; Transfection; MTT; EdU Staining; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; ELISA; Western Blot; Luciferase Reporter Assay
Clinical significance:

-
Description:

circASH2L (hsa_circ_0083964), derived from ASH2L, is up-regulated in RA synovial tissues and RA-FLSs. It promotes RA-FLS tumor-like behaviors (proliferation, migration, invasion, cell cycle progression), inhibits apoptosis, and enhances inflammatory cytokine production by sponging miR-129-5p to increase HIPK2 expression.
Confidence score:

0.6973
Other information
Title:

CircASH2L facilitates tumor-like biologic behaviours and inflammation of fibroblast-like synoviocytes via miR-129-5p/HIPK2 axis in rheumatoid arthritis.

Journal: Journal of orthopaedic surgery and research
Published: 2021
PubMed ID: 33964939
Study type:

combined biological and clinical study
Data availability: -
Code availability: -