circRNA basic information
circBase ID: -
Name: hsa_circ_PDLIM5
Synonym: circPDLIM5
Host Gene: PDLIM5
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: extracellular vesicle
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: high-grade prostate cancer
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

urine extracellular vesicles
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Diagnostic biomarker component of a urine extracellular vesicle circRNA classifier (Ccirc) for detecting ≥GG2 prostate cancer.
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; Cohort Study; ROC Analysis; ddPCR
Clinical significance:

Part of a 5-circRNA urine extracellular vesicle classifier (Ccirc) that improves prediction of ≥GG2 prostate cancer at initial biopsy compared with standard risk calculators.
Description:

circPDLIM5 is elevated in urine extracellular vesicles from patients with high-grade (≥GG2) prostate cancer and is one of five circRNAs used to construct the Ccirc classifier. Its measured level contributes to noninvasive detection and risk prediction of clinically significant PCa at initial biopsy.
Confidence score:

0.5414
Other information
Title:

A urine extracellular vesicle circRNA classifier for detection of high-grade prostate cancer in patients with prostate-specific antigen 2-10 ng/mL at initial biopsy.

Journal: Molecular cancer
Published: 2021
PubMed ID: 34301266
Study type:

combined biological and clinical study
Data availability: GSE147761
Code availability: -