circRNA basic information
circBase ID: hsa_circ_0088300
Name: -
Synonym: circ_0088300
Host Gene: -
Genomic location(hg19): chr9:123593608-123595734:-
Genomic location(hg38): chr9:120831330-120833456:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma; gastric cancer tissue samples; adjacent normal tissue samples
Cell lines:

MKN-45; AGS
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: BOLL
Associated microRNA: -
Biological function: circ_0088300 promotes gastric cancer cell proliferation, migration, invasion, EMT progression, glycolysis, metabolic reprogramming, tumor growth and metastasis by upregulating BOLL protein.
Molecular mechanism: circ_0088300 interacts with the RNA-binding protein BOLL, forms RNA-protein complexes, upregulates BOLL protein expression, and promotes mitochondrial metabolic reprogramming and aerobic glycolysis in gastric cancer cells.
Biological pathway or process:

glycolysis (promotes); oxidative phosphorylation (inhibits); mitochondrial function (other); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); other pathway/process (promotes)
Detected method:
Q
M
Validation methods:

RT-qPCR; Microarray; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; IF (Immunofluorescence); Transwell Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

The circ_0088300/BOLL axis could be investigated as a potential therapeutic target and diagnostic biomarker in gastric cancer, but its impact on survival and prognosis requires further confirmation.
Description:

This study identifies hsa_circ_0088300/circ_0088300 as an upregulated circRNA in gastric cancer-related GEO data. circ_0088300 interacts with the RBP BOLL and increases BOLL protein expression, thereby promoting glycolysis, mitochondrial metabolic reprogramming, proliferation, migration, invasion, EMT, and gastric cancer growth and metastasis. The circ_0088300/BOLL axis is proposed as a potential therapeutic target and diagnostic biomarker, although prognostic relevance remains unconfirmed.
Confidence score:

0.657
Other information
Title:

Molecular Mechanism of Circ_0088300-BOLL Interaction Regulating Mitochondrial Metabolic Reprogramming and Involved in Gastric Cancer Growth and Metastasis.

Journal: Journal of proteome research
Published: 2023
PubMed ID: 37953520
Study type:

combined biological and bioinformatics study
Data availability: TCGA; GSE93541; GEPIA; RPISeq; Supporting Information
Code availability: -