| Expression pattern: |
UP |
| Associated gene: |
IGF1R, Ago2 |
| Associated microRNA: |
miR-940 |
| Biological function: |
Circ_0006174 promotes CRC tumor growth and radioresistance, enhances proliferation, migration and invasion, and inhibits apoptosis; circ_0006174 knockdown enhances radiosensitivity and suppresses malignant phenotypes in vitro and tumor growth in vivo. |
| Molecular mechanism: |
Circ_0006174 functions as a ceRNA/miRNA sponge for miR-940, thereby upregulating IGF1R expression and promoting CRC radioresistance and tumorigenesis. |
| Biological pathway or process: |
ceRNA regulation (promotes); radioresistance (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; Colony Formation Assay; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
Circ_0006174 expression was significantly related to tumor TNM stage and its high expression in CRC primary tumors implied potential diagnostic marker value; it may be a promising therapeutic target for improving CRC treatment. |
| Description: |
Circ_0006174 is up-regulated in colorectal cancer tissues and cells and is associated with tumor TNM stage. Functionally, it promotes CRC tumorigenesis and radioresistance by enhancing proliferation, migration and invasion while suppressing apoptosis. Mechanistically, circ_0006174 sponges miR-940 to increase IGF1R expression, forming a circ_0006174/miR-940/IGF1R regulatory axis. |
| Confidence score: |
0.7552 |