| Expression pattern: |
UP |
| Associated gene: |
GINS4, Rac1, CDC42 |
| Associated microRNA: |
miR-509-3-5p |
| Biological function: |
promotes cell proliferation, cell cycle and metastasis, and suppresses cell apoptosis in gastric cancer |
| Molecular mechanism: |
circMLLT10 functions as a ceRNA/miRNA sponge for miR-509-3-5p to relieve repression of GINS4, activating Rac1/CDC42 downstream signaling |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); MAPK/ERK (promotes); PI3K/AKT (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; Bioinformatics Analysis; Luciferase Reporter Assay; RT-qPCR; FISH / smFISH; Transfection; MTT; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot |
| Clinical significance: |
- |
| Description: |
circMLLT10 is up-regulated in gastric cancer and mainly localizes in the cytoplasm. It functions as a ceRNA by sponging miR-509-3-5p, relieving repression of GINS4 and promoting Rac1/CDC42 activation, thereby enhancing proliferation and metastasis while inhibiting apoptosis. |
| Confidence score: |
0.6742 |