| Expression pattern: |
DN |
| Associated gene: |
MAFB, RANKL, OPG, NF-kappaB p65, IL-1beta, IL-6, MDA, GSH |
| Associated microRNA: |
miR-338-3p |
| Biological function: |
Downregulation is linked to postmenopausal osteoporosis severity; circ-HIPK3 is suggested to counteract miR-338-3p-mediated MAFB suppression and bone homeostasis imbalance. |
| Molecular mechanism: |
ceRNA mechanism involving circ-HIPK3 and miR-338-3p, with miR-338-3p upregulation inhibiting MAFB expression and contributing to bone homeostasis imbalance. |
| Biological pathway or process: |
ceRNA regulation (inhibits); other pathway/process (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Western Blot; ELISA; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Potential biomarker for early detection of osteoporosis and tracking its progression; circ-HIPK3 discriminated osteopenic and osteoporotic patients from controls and predicted progression of osteoporosis. |
| Description: |
circ-HIPK3 was downregulated in PBMCs from postmenopausal women with osteopenia and osteoporosis, with lower expression associated with greater disease severity. The study suggests that reduced circ-HIPK3 permits miR-338-3p upregulation, leading to MAFB inhibition and bone homeostasis imbalance; circ-HIPK3 also showed utility as a diagnostic and progression-tracking biomarker. |
| Confidence score: |
0.6032 |