| Expression pattern: |
DN |
| Associated gene: |
EIF4A3, MST1, LATS1, YAP1 |
| Associated microRNA: |
- |
| Biological function: |
hsa_circ_0049396 attenuates NPC tumorigenesis by suppressing proliferation, migration, invasion, and tumor growth in vivo. |
| Molecular mechanism: |
EIF4A3 binds to the flanking regions of hsa_circ_0049396 and enhances its expression; hsa_circ_0049396 suppresses activation of the Hippo-YAP pathway. |
| Biological pathway or process: |
Hippo/YAP (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Survival Analysis; Transfection; CCK8; EdU Staining; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; Bioinformatics Analysis; Western Blot; RIP (RNA Immunoprecipitation) |
| Clinical significance: |
low expression indicated poor prognosis; may serve as a potential diagnostic biomarker or drug target in NPC |
| Description: |
hsa_circ_0049396 is downregulated in nasopharyngeal carcinoma tissues and cells, and low expression is associated with poor prognosis. EIF4A3 enhances hsa_circ_0049396 expression by binding its flanking regions, while hsa_circ_0049396 overexpression suppresses NPC proliferation, migration, invasion, and xenograft tumor growth through inhibition of the Hippo-YAP pathway. The study suggests hsa_circ_0049396 as a potential diagnostic biomarker or drug target for NPC. |
| Confidence score: |
0.7661 |