circRNA basic information
circBase ID: hsa_circ_0023826
Name: hsa_circ_ODZ4
Synonym: circ_0023826
Host Gene: hsa-miR-188-3p
 
 
 
Disease basic information
DO ID:
 1686
DO name: glaucoma
Disease details: glaucoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: MDM4
Associated microRNA: hsa-miR-188-3p
Biological function: Upregulating circ_0023826 attenuated the visual impairment in rats and promoted the survival of RGCs in vitro
Molecular mechanism: circ_0023826/hsa-miR-188-3p/MDM4 axis, miRNA sponge
Survival: -
Supported No.:
 2
Description:

Overall, circ_0023826 protects against glaucoma by regulating the miR-188-3p/MDM4 axis, and targeted intervention of circ_0023826 expression is a promising therapeutic strategy for the treatment of retinal neurodegeneration.
Other information
Title:

Hsa_circ_0023826 protects against glaucoma by regulating miR-188-3p/MDM4 axis.

Journal: Acta Biochim Pol
Published: 2023/6/12
PubMed ID: 37306552