| Expression pattern: |
UP |
| Associated gene: |
IGF2, PI3K, AKT, Bax, cleaved caspase3 |
| Associated microRNA: |
miR-490-5p |
| Biological function: |
circ_0001361 promotes neuroblastoma cell viability/proliferation and suppresses apoptosis; its knockdown inhibits viability/proliferation and promotes apoptosis. |
| Molecular mechanism: |
circ_0001361 functions as a miR-490-5p sponge and regulates IGF2, leading to PI3K/AKT pathway activation and modulation of apoptosis-related proteins. |
| Biological pathway or process: |
PI3K/AKT (promotes); apoptosis (inhibits); proliferation (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; Bioinformatics Analysis |
| Clinical significance: |
circ_0001361 is suggested as a potential therapeutic target for neuroblastoma. |
| Description: |
In neuroblastoma, circ_0001361 is up-regulated in tumor tissues and NB cell lines. The study supports an oncogenic role in which circ_0001361 sponges miR-490-5p to regulate IGF2 and activate PI3K/AKT signaling, thereby promoting cell viability/proliferation and inhibiting apoptosis. Knockdown of circ_0001361 suppresses NB cell viability and promotes apoptosis, suggesting potential therapeutic relevance. |
| Confidence score: |
0.6996 |