circRNA basic information
circBase ID: hsa_circ_0079440
Name: hsa_circ_PHF14
Synonym: circ_0079440
Host Gene: PHF14
Genomic location(hg19): chr7:11101417-11151094:+
Genomic location(hg38): chr7:11061790-11111467:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009831
MONDO name: malignant pancreatic neoplasm
Disease details: Pancreatic cancer
Disease DO ID:
 1793
Disease MeSH ID:
 -
Disease NCIt ID:
 C9005
Disease ICD11 ID:
 542147910
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; paracancerous tissues; mouse tumor tissues; mouse lungs
Cell lines:

CFPAC-1; SW1990; HPNE; HPDE
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: EIF4A1, Ago2, RISC
Associated microRNA: miR-522-3p
Biological function: circ_0079440 functions as an oncogene in pancreatic cancer, facilitating cell growth, proliferation, migration, invasion, EMT, tumor growth, and lung metastasis; curcumin suppresses these malignant phenotypes by downregulating circ_0079440.
Molecular mechanism: circ_0079440 acts as a cytoplasmic ceRNA/molecular sponge for miR-522-3p, thereby upregulating EIF4A1 expression; curcumin downregulates circ_0079440 and EIF4A1 and upregulates miR-522-3p.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); metastasis (promotes)
Detected method:
Q
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; FISH / smFISH; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Western Blot; Bioinformatics Analysis
Clinical significance:

Potential therapeutic target for treatment of pancreatic cancer.
Description:

circ_0079440 is up-regulated in pancreatic cancer tissues and cell lines and acts as an oncogenic circRNA. It promotes proliferation, migration, invasion, EMT, tumor growth, and metastasis through a cytoplasmic ceRNA mechanism involving miR-522-3p and EIF4A1. Curcumin suppresses pancreatic cancer progression by downregulating circ_0079440 and thereby inhibiting the circ_0079440/miR-522-3p/EIF4A1 pathway.
Confidence score:

0.8689
Other information
Title:

Curcumin Inhibits the Development of Pancreatic Cancer by Targeting the circ_0079440/miR-522-3p/EIF4A1 Pathway.

Journal: Cell biochemistry and biophysics
Published: 2025
PubMed ID: 39102088
Study type:

combined biological and clinical study
Data availability: Supplementary material available at https://doi.org/10.1007/s12013-024-01466-8
Code availability: -