| Expression pattern: |
DN |
| Associated gene: |
YWHAG |
| Associated microRNA: |
miR-146a-5p |
| Biological function: |
Improves renal function, reduces inflammatory factor content and fibrosis marker expression, and alleviates renal pathological damage in CGN rats. |
| Molecular mechanism: |
circ-ITCH acts as a sponge for miR-146a-5p and regulates YWHAG expression through the miR-146a-5p/YWHAG axis. |
| Biological pathway or process: |
inflammation (inhibits); fibrosis (inhibits); ceRNA regulation (promotes); other pathway/process (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; ELISA; Western Blot; IF (Immunofluorescence); In Vivo Animal Model; H&E Staining |
| Clinical significance: |
Circ-ITCH may be an effective target for CGN, providing a new reference and strategy for clinical treatment. |
| Description: |
circ-ITCH is downregulated in C-BSA-induced CGN rats. Its overexpression improves renal function and reduces inflammation, fibrosis marker expression, IgG deposition, and renal pathological injury, acting through a miR-146a-5p/YWHAG ceRNA axis. |
| Confidence score: |
0.5627 |