| Expression pattern: |
UP |
| Associated gene: |
PAIP1 |
| Associated microRNA: |
miR-1305 |
| Biological function: |
Promotes cervical cancer cell proliferation, migration, invasion and tumor growth; acts as an oncogenic factor. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-1305 to upregulate PAIP1 (ceRNA mechanism). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; Cell Cycle Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation |
| Clinical significance: |
circ_0005576 might be a potential biomarker/therapeutic target for cervical cancer treatment. |
| Description: |
circ_0005576 is up-regulated in cervical cancer tissues/cells and functions as an oncogenic circRNA. It mainly localizes to the cytoplasm and promotes malignant phenotypes by sponging miR-1305 to increase PAIP1 expression, thereby enhancing tumor growth in vitro and in vivo. |
| Confidence score: |
0.8039 |