circRNA basic information
circBase ID: hsa_circ_0002202
Name: hsa_circ_SAMD4A
Synonym: -
Host Gene: SMAD4A
Genomic location(hg19): chr14:55071089-55169298:+
Genomic location(hg38): chr14:54604371-54702580:+
Subcellular localization: nucleus and cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005147
MONDO name: type 1 diabetes mellitus
Disease details: Type 1 diabetes mellitus
Disease DO ID:
 9744
Disease MeSH ID:
 D003922
Disease NCIt ID:
 C2986
Disease ICD11 ID:
 1651053999
Disease OMIM ID:
 222100
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood mononuclear cells (PBMCs)
Cell lines:

THP-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: GREM2, IFIT1, IFIH1, CXCL10, iNOS
Associated microRNA: miR-495-3p, miR-668-3p, miR-508-3p, miR-487a-3p
Biological function: promotes IFN-I-induced macrophage inflammation
Molecular mechanism: ceRNA mechanism (miRNA sponge) involving multiple miRNAs and the target gene GREM2
Biological pathway or process:

inflammation (inhibits); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Transfection
Clinical significance:

-
Description:

hsa_circ_0002202 is up-regulated in PBMCs from T1DM patients and is mainly localized in the cytoplasm of THP-1-derived macrophages. Functional knockdown experiments indicate it promotes IFN-I-induced inflammatory responses, and bioinformatic ceRNA analysis links it to a miRNA-mediated regulatory module (miR-495-3p/miR-668-3p/miR-508-3p/miR-487a-3p) targeting GREM2.
Confidence score:

0.3514
Other information
Title:

Understanding Competitive Endogenous RNA Network Mechanism in Type 1 Diabetes Mellitus Using Computational and Bioinformatics Approaches.

Journal: Diabetes, metabolic syndrome and obesity : targets and therapy
Published: 2021
PubMed ID: 34526791
Study type:

combined biological and clinical study
Data availability: GSE133225; GSE133217; Supplementary File 1; Supplementary File 2; Supplementary File 3
Code availability: -