| Expression pattern: |
UP |
| Associated gene: |
EIF4A3 |
| Associated microRNA: |
- |
| Biological function: |
Promotes gastric cancer cell proliferation and migration/motility; knockdown inhibits proliferation, invasion/migration. |
| Molecular mechanism: |
Binds the RNA-binding protein EIF4A3; positively associated with EIF4A3; EIF4A3 overexpression rescues circ_0074027 knockdown effects. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; RIP (RNA Immunoprecipitation); Western Blot; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circ_0074027 is up-regulated in gastric cancer cell lines and promotes GC cell proliferation and motility. Mechanistically, circ_0074027 binds the RNA-binding protein EIF4A3, and EIF4A3 overexpression reverses the inhibitory effects caused by circ_0074027 knockdown. |
| Confidence score: |
0.7177 |