| Expression pattern: |
DS |
| Associated gene: |
EIF4A3 |
| Associated microRNA: |
- |
| Biological function: |
Component of an 8-circRNA noninvasive serum diagnostic biomarker panel for GC. |
| Molecular mechanism: |
Not experimentally characterized; discussed potential interaction with RBP EIF4A3 for most panel circRNAs. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; divergent primers PCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Included in the validated 8-circRNA serum risk-prediction model for GC diagnosis and early-stage detection. |
| Description: |
hsa_circ_0034398 is one of the eight circRNAs measurable in serum and used to build a logistic regression risk model for gastric cancer diagnosis. It was discovered in microarray datasets and validated by RT-qPCR in tissue and serum cohorts. |
| Confidence score: |
0.6556 |