circRNA basic information
circBase ID: hsa_circ_0080914
Name: hsa_circ_HGF
Synonym: circHGF
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3073
DO name: brain glioblastoma multiforme
Disease details: glioblastoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MET
Associated microRNA: -
Biological function: Knockdown of C-HGF resulted in suppression of c-MET signaling and marked inhibition of cell growth, motility and invasiveness, whereas overexpression of C-HGF displayed the opposite effects
Molecular mechanism: circHGF/MET axis
Survival: -
Supported No.:
 1
Description:

These results reveal an alternative mechanism of c-MET activation via a circular RNA encoded HGF protein variant which is relevant in GBM biology.
Other information
Title:

Translation of circHGF RNA encodes an HGF protein variant promoting glioblastoma growth through stimulation of c-MET.

Journal: J Neurooncol
Published: 2023/5/10
PubMed ID: 37162666