| Expression pattern: |
DS |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-330-5p |
| Biological function: |
May be related to chronic bronchitis pathology and may be a potential therapeutic target for LC with COPD. |
| Molecular mechanism: |
The study tested a predicted hsa-miR-330-5p sponge relationship, but concluded that circRNA_21279 cannot regulate hsa-miR-330-5p involvement in disease progression through the ceRNA mechanism; no confirmed molecular mechanism was specified. |
| Biological pathway or process: |
other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
May be a potential therapeutic target for LC with COPD. |
| Description: |
circRNA_21729 was identified through microarray/WGCNA as a candidate circRNA associated with chronic bronchitis pathology in LC patients with COPD, and its expression pattern was validated by RT-qPCR. Although hsa-miR-330-5p was predicted as a sponged miRNA, the authors concluded that circRNA_21279/circRNA_21729 likely does not regulate hsa-miR-330-5p through a ceRNA mechanism in disease progression. |
| Confidence score: |
0.5135 |