| Expression pattern: |
UP |
| Associated gene: |
TRIM27 |
| Associated microRNA: |
miR-136-5p |
| Biological function: |
promotes proliferation, migration, invasion, cell cycle progression and EMT; inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: circ_0091579 sponges miR-136-5p to up-regulate TRIM27 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); cell cycle (promotes); apoptosis (inhibits); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; divergent primers PCR; Nuclear-Cytoplasmic Fractionation; Northern Blot; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
HCC patients with high circ_0091579 expression displayed low survival rate; associated with advanced TNM stage and large tumor size; potential prognostic biomarker |
| Description: |
Circ_0091579 is up-regulated in hepatocellular carcinoma and is associated with poorer survival. Functionally, it promotes HCC cell proliferation, migration/invasion, cell-cycle progression and EMT while inhibiting apoptosis, and it enhances xenograft tumor growth. Mechanistically, circ_0091579 mainly localizes to the cytoplasm and acts as a ceRNA sponge for miR-136-5p to up-regulate TRIM27. |
| Confidence score: |
0.8498 |