circRNA basic information
circBase ID: hsa_circ_0085440
Name: -
Synonym: circ_0085440
Host Gene: -
Genomic location(hg19): chr8:124089350-124121860:+
Genomic location(hg38): chr8:123077110-123109620:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor specimens; HCC tumors
Cell lines:

Huh-7; Hep3B
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: GHRHR
Associated microRNA: miR-205-5p
Biological function: The GLIS3-209/circ_0085440-miR-205-5p-GHRHR axis inhibited HCC cell proliferation in vitro.
Molecular mechanism: ceRNA mechanism involving circ_0085440, miR-205-5p, and GHRHR mRNA in a down-up-down regulatory axis associated with CTNNB1 mutations.
Biological pathway or process:

proliferation (inhibits); ceRNA regulation (other)
Detected method:
S
Validation methods:

RNase R Treatment; circRNA-seq; Bioinformatics Analysis; RT-qPCR; Transfection; CCK8; Colony Formation Assay; Western Blot
Clinical significance:

-
Description:

circ_0085440 was included in a down-up-down CTNNB1 mutation-associated ceRNA axis, GLIS3-209/circ_0085440-miR-205-5p-GHRHR. The study suggests that reduced circ_0085440 is linked with increased miR-205-5p and decreased GHRHR, contributing to inhibition of HCC cell proliferation.
Confidence score:

0.6207
Other information
Title:

Integrated analysis of ncRNA in hepatocellular carcinoma with CTNNB1 mutations reveals miR-205-5p and miR-3940-3p Axes.

Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Published: 2025
PubMed ID: 38918127
Study type:

combined biological and clinical study
Data availability: Data will be made available on request; TCGA; cBioPortal; UALCAN; Supplementary material associated with this article can be found, in the online version, at doi:10.1016/j.dld.2024.06.001
Code availability: -