circRNA basic information
circBase ID: hsa_circ_0021570
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr11:32948702-32956981:+
Genomic location(hg38): chr11:32927156-32935435:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma / OS
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HUO3N1; CAL78; hFOB1.19; NOS1; U2OS; HOS
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: 73 mRNAs
Associated microRNA: hsa-miR-892c-3p, hsa-miR-4676-3p
Biological function: Potentially participates in osteosarcoma metastasis and is associated with cancer-related pathways in the predicted ceRNA network.
Molecular mechanism: circRNA-based competing endogenous RNA network involving miRNAs and mRNAs
Biological pathway or process:

ceRNA regulation (other); metastasis (other); mTOR signaling pathway (other); stemness (other); drug resistance (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0021570 was identified as a differentially expressed, metastasis-related circRNA in osteosarcoma cell lines and incorporated into a predicted ceRNA network. Bioinformatic enrichment linked it to cancer-related pathways, including mTOR signaling and EGFR tyrosine kinase inhibitor resistance.
Confidence score:

0.1768
Other information
Title:

Comprehensive characterization of circular RNAs in osteosarcoma cell lines.

Journal: Cellular signalling
Published: 2020
PubMed ID: 32199934
Study type:

bioinformatics study
Data availability: SRP157750; TARGET database; Supplementary data: https://doi.org/10.1016/j.cellsig.2020.109603
Code availability: -