| Expression pattern: |
DN |
| Associated gene: |
Smad4, AKT |
| Associated microRNA: |
miR-378 |
| Biological function: |
promotes apoptosis; inhibits proliferation, migration, invasion, angiogenesis, and abdominal metastasis in ovarian cancer |
| Molecular mechanism: |
acts as a miR-378 sponge to disinhibit Smad4 and modulate AKT phosphorylation/signaling |
| Biological pathway or process: |
ceRNA regulation (promotes); AKT signaling (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); angiogenesis (inhibits); apoptosis (promotes); metastasis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; FISH / smFISH; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Tube Formation Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Clinical Sample Validation; Survival Analysis |
| Clinical significance: |
Low circATRNL1 level is correlated with poor survival rate; circATRNL1 may serve as a biomarker for ovarian cancer |
| Description: |
circATRNL1 is down-regulated in ovarian cancer and acts as a tumor suppressor. It sponges miR-378 to relieve repression of Smad4, thereby inhibiting AKT signaling, reducing proliferation/migration/invasion/angiogenesis and metastasis, and higher circATRNL1 predicts better survival. |
| Confidence score: |
0.7829 |