| Expression pattern: |
UP |
| Associated gene: |
P-gp, Abcb1b, ADAR2 |
| Associated microRNA: |
miR-195a-3p |
| Biological function: |
circHif1a functions as a sponge for miR-195a-3p, upregulates P-gp/Abcb1b expression, reduces intracellular doxorubicin accumulation, and contributes to decreased susceptibility to doxorubicin in murine breast cancer cells. |
| Molecular mechanism: |
ADAR2 suppresses circHif1a biogenesis; increased circHif1a sponges miR-195a-3p, relieving miR-195a-3p-mediated repression of Abcb1b/P-gp and promoting chemoresistance. |
| Biological pathway or process: |
ceRNA regulation (promotes); drug resistance (promotes); chemoresistance (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; Luciferase Reporter Assay; Transfection; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
May help improve drug efficacy by clarifying the mechanism of chemoresistance in breast cancer. |
| Description: |
In murine 4T1 breast cancer cells, ADAR2 knockdown increases circHif1a expression. circHif1a acts as a miR-195a-3p sponge, causing increased Abcb1b/P-gp expression and reduced susceptibility to doxorubicin, thereby contributing to chemoresistance. |
| Confidence score: |
0.686 |