| Expression pattern: |
UP |
| Associated gene: |
KLF8 |
| Associated microRNA: |
miR-198 |
| Biological function: |
Circ_0004015 promotes DDP resistance, NSCLC cell proliferation, migration and invasion, and inhibits apoptosis; silencing circ_0004015 improves cisplatin sensitivity and suppresses tumor formation. |
| Molecular mechanism: |
Circ_0004015 acts as a ceRNA/sponging RNA for miR-198, thereby increasing KLF8 expression and promoting DDP resistance and NSCLC progression. |
| Biological pathway or process: |
chemoresistance (promotes); drug resistance (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
Circ_0004015 was upregulated in DDP-resistant NSCLC tissues and may be a potential therapeutic target for DDP-mediated treatment of NSCLC. |
| Description: |
Circ_0004015 is upregulated in DDP-resistant NSCLC tissues and cells. It promotes cisplatin resistance and malignant phenotypes by sponging miR-198 and increasing KLF8 expression, while circ_0004015 knockdown sensitizes NSCLC cells and xenograft tumors to DDP. |
| Confidence score: |
0.7595 |