circRNA basic information
circBase ID: hsa_circ_0004015
Name: hsa_circ_CDK14
Synonym: circ_0004015
Host Gene: CDK14
Genomic location(hg19): chr7:90355880-90377090:+
Genomic location(hg38): chr7:90726566-90747775:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
3908
Disease MeSH ID:
D002289
Disease NCIt ID:
C2926
Disease ICD11 ID:
-
Disease OMIM ID:
-
Species: Human
Species details: Homo sapiens
Tissue specimen:

normal lung tissues; DDP-resistant NSCLC tissues; DDP-sensitive NSCLC tissues

Cell lines:

16HBE; A549; H1299; A549/DDP; H1299/DDP

In vivo animal model:

cell line-derived xenograft

circRNA-disease information
Expression pattern:
UP
Associated gene: KLF8
Associated microRNA: miR-198
Biological function: Circ_0004015 promotes DDP resistance, NSCLC cell proliferation, migration and invasion, and inhibits apoptosis; silencing circ_0004015 improves cisplatin sensitivity and suppresses tumor formation.
Molecular mechanism: Circ_0004015 acts as a ceRNA/sponging RNA for miR-198, thereby increasing KLF8 expression and promoting DDP resistance and NSCLC progression.
Biological pathway or process:

chemoresistance (promotes); drug resistance (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes)

Detected method:
Q
Validation methods:

RNase R Treatment; RT-qPCR; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; Western Blot; Bioinformatics Analysis

Clinical significance:

Circ_0004015 was upregulated in DDP-resistant NSCLC tissues and may be a potential therapeutic target for DDP-mediated treatment of NSCLC.

Description:

Circ_0004015 is upregulated in DDP-resistant NSCLC tissues and cells. It promotes cisplatin resistance and malignant phenotypes by sponging miR-198 and increasing KLF8 expression, while circ_0004015 knockdown sensitizes NSCLC cells and xenograft tumors to DDP.

Confidence score:

0.7595

Other information
Title:

Circ_0004015 silencing represses cisplatin chemoresistance and tumor progression by reducing KLF8 in a miR-198-dependent manner in non-small cell lung cancer.

Journal: Genomics
Published: 2022
PubMed ID: 35134495
Study type:

combined biological and clinical study

Data availability: -
Code availability: -