| Expression pattern: |
UP |
| Associated gene: |
HIF1A |
| Associated microRNA: |
miR-578 |
| Biological function: |
Promotes breast cancer malignant progression (cell viability, colony formation, migration, invasion, glycolysis) and inhibits apoptosis. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-578 to regulate HIF1A expression (ceRNA-like mechanism). |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); glycolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Transfection; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
circZFR was overexpressed in BC tissues and cells, and the increased circZFR level predicted poor prognosis of BC patients. |
| Description: |
circZFR is up-regulated in breast cancer and its high expression correlates with worse overall survival. Functionally, circZFR promotes malignant phenotypes (proliferation/colony formation, migration/invasion, glycolysis) and suppresses apoptosis. Mechanistically, circZFR sponges miR-578 to de-repress HIF1A, forming a circZFR/miR-578/HIF1A regulatory axis. |
| Confidence score: |
0.7552 |