circRNA basic information
circBase ID: hsa_circ_0006168
Name: hsa_circ_CNOT6L
Synonym: hsa_circRNA_103670
Host Gene: CNOT6L
Genomic location(hg19): chr4:78694234-78697546:-
Genomic location(hg38): chr4:77773080-77776392:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004986
MONDO name: urinary bladder carcinoma
Disease details: bladder cancer
Disease DO ID:
 4007
Disease MeSH ID:
 -
Disease NCIt ID:
 C4912
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

BCa tissue; para-carcinoma normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-570-5p, miR-592, miR-542-3p, miR-628-5p, miR-148b-5p
Biological function: unknown
Molecular mechanism: Predicted miRNA sponge (MRE prediction) in BCa
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

High expression of hsa_circRNA_103670 was related to the high histological grade, poor T stage.
Description:

hsa_circRNA_103670 is up-regulated in bladder cancer tissues versus paired para-carcinoma normal tissues (microarray and RT-qPCR validation). The study predicts it may act as a miRNA sponge, with candidate target miRNAs including miR-570-5p, miR-592, miR-542-3p, miR-628-5p and miR-148b-5p. Higher hsa_circRNA_103670 expression is associated with high histological grade and poor T stage.
Confidence score:

0.5135
Other information
Title:

Microarray Expression Profiles and Bioinformatics Analyses Reveal Aberrant Circular RNAs Expression in Bladder Cancer.

Journal: OncoTargets and therapy
Published: 2020
PubMed ID: 33149606
Study type:

combined biological and clinical study
Data availability: Supplementary data 1; Supplementary data 2; Supplementary data 3
Code availability: -