circRNA basic information
circBase ID: hsa_circ_0078328
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr6:152650864-152653025:-
Genomic location(hg38): chr6:152329729-152331890:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008608
MONDO name: Down syndrome
Disease details: Down syndrome
Disease DO ID:
 14250
Disease MeSH ID:
 D004314
Disease NCIt ID:
 C2993
Disease ICD11 ID:
 1624623908
Disease OMIM ID:
 190685
Species: Human
Species details: Homo sapiens
Tissue specimen:

fetal hippocampus tissues
Cell lines:

293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: EZH2
Associated microRNA: hsa-miR-138-5p
Biological function: Acts as a competing endogenous RNA (RNA sponge) for miR-138-5p to participate in regulation of EZH2, potentially affecting hippocampus development in DS.
Molecular mechanism: ceRNA sponge of miR-138-5p regulating EZH2 expression
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection
Clinical significance:

-
Description:

In fetal hippocampus Down syndrome samples, hsa_circ_0078328 is implicated as a ceRNA that directly binds miR-138-5p and may modulate EZH2, potentially influencing hippocampal development. The circRNA-miRNA interaction was supported by dual-luciferase assay in 293T cells.
Confidence score:

0.5618
Other information
Title:

Integrative Analysis Extracts a Core ceRNA Network of the Fetal Hippocampus With Down Syndrome.

Journal: Frontiers in genetics
Published: 2020
PubMed ID: 33329702
Study type:

combined biological and clinical study
Data availability: GSE131258
Code availability: -