| Expression pattern: |
DN |
| Associated gene: |
SLC15A4 |
| Associated microRNA: |
hsa-miR-124-3p |
| Biological function: |
May participate in cell proliferation and invasion of eutopic endometrium in ADS; decreased expression is associated with increased ADS risk and has diagnostic biomarker value. |
| Molecular mechanism: |
ceRNA mechanism; hsa_circ_0008959 may sponge hsa-miR-124-3p to regulate SLC15A4 expression. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (other); invasion (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNase R Treatment; circRNA-seq; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Decreased hsa_circ_0008959 was identified as a risk factor for ADS development; hsa_circ_0008959 showed diagnostic value for ADS, with AUC 0.826 alone and 0.976 when combined with VAS score. |
| Description: |
hsa_circ_0008959 is significantly down-regulated in eutopic endometrium from ADS patients. The study proposes that it functions as a ceRNA by sponging hsa-miR-124-3p to regulate SLC15A4, thereby participating in proliferation and invasion-related processes and showing diagnostic value for ADS. |
| Confidence score: |
0.6238 |