circRNA basic information
circBase ID: hsa_circ_0044556
Name: hsa_circ_COL1A1
Synonym: circRNA_0044556
Host Gene: COL1A1
Genomic location(hg19): chr17:48271490-48272189:-
Genomic location(hg38): chr17:50194129-50194828:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005494
MONDO name: triple-negative breast carcinoma
Disease details: triple-negative breast cancer
Disease DO ID:
 0060081
Disease MeSH ID:
 D064726
Disease NCIt ID:
 C71732
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

MDA-MB-231; MDA-MB-231/PTX; MCF-10A
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-665
Biological function: Promotes malignant phenotype, proliferation, colony formation and paclitaxel resistance of TNBC cells; inhibits apoptosis.
Molecular mechanism: circRNA_0044556 acts as a ceRNA by sponging miR-665 to regulate TNBC malignant phenotype and paclitaxel resistance.
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); chemoresistance (promotes); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot
Clinical significance:

circRNA_0044556 may be a potential therapeutic target for PTX-resistant TNBC.
Description:

circRNA_0044556 is up-regulated in TNBC cells and further increased in paclitaxel-resistant MDA-MB-231/PTX cells. It promotes TNBC malignant phenotypes and paclitaxel resistance by acting as a ceRNA for miR-665; knockdown reduces proliferation and colony formation and induces apoptosis, suggesting therapeutic potential in PTX-resistant TNBC.
Confidence score:

0.5607
Other information
Title:

CircRNA_0044556 affects the sensitivity of triple-negative breast cancer cells to paclitaxel by regulating miR-665.

Journal: Journal of chemotherapy (Florence, Italy)
Published: 2025
PubMed ID: 38850033
Study type:

biological research
Data availability: The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -