| Expression pattern: |
UP |
| Associated gene: |
TXNDC5 |
| Associated microRNA: |
miR-382-5p, miR-383-5p |
| Biological function: |
hsa_circ_0070440 facilitates PCa cell proliferation and migration; knockdown inhibits proliferation and migration; high expression is associated with worse prognosis and CRPC progression. |
| Molecular mechanism: |
hsa_circ_0070440 may act as a ceRNA sponge for miR-382-5p and miR-383-5p, thereby involving the target gene TXNDC5 in PCa progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); ceRNA regulation (other); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay |
| Clinical significance: |
High hsa_circ_0070440 expression is associated with clinical T stage and lymph node metastasis and predicts worse overall survival, TTPP, and TTF as an independent prognostic factor. |
| Description: |
hsa_circ_0070440 is up-regulated in prostate cancer tissues and cell lines, with higher levels in CRPC than non-CRPC cases. Its high expression predicts poor OS, TTPP, and TTF, and functional assays indicate that it promotes PCa cell proliferation and migration. Mechanistically, it may sponge miR-382-5p and miR-383-5p and participate in a miR-382/383-5p/TXNDC5 regulatory axis. |
| Confidence score: |
0.7283 |