| Expression pattern: |
UP |
| Associated gene: |
Sp1, THBS1, THBS1 promoter |
| Associated microRNA: |
- |
| Biological function: |
Promotes pancreatic cancer cell proliferation, migration, invasion, EMT-related changes, and metastasis in vitro and in vivo. |
| Molecular mechanism: |
hsa_circ_0007919 is mainly nuclear and recruits the transcription factor Sp1 to the THBS1 promoter, inhibiting THBS1 transcription and thereby promoting pancreatic cancer metastasis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); other pathway/process (other) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; RNA-seq; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); ChIP / ChIP-seq; Transfection; CCK8; Transwell Assay; Western Blot; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High hsa_circ_0007919 expression is correlated with lymph node metastasis, TNM stage, and poor prognosis; it may serve as a prognostic biomarker and therapeutic target in pancreatic cancer. |
| Description: |
hsa_circ_0007919 is up-regulated in pancreatic cancer tissues and cells and its high expression is associated with lymph node invasion, TNM stage, and poor overall survival. Functionally, it promotes proliferation, migration, invasion, EMT-related marker changes, and metastasis. Mechanistically, the nuclear circRNA recruits Sp1 to the THBS1 promoter to inhibit THBS1 transcription, supporting pancreatic cancer metastatic progression. |
| Confidence score: |
0.8655 |