circRNA basic information
circBase ID: hsa_circ_0000066
Name: hsa_circ_RNF220
Synonym: hsa_circ_0000066b
Host Gene: RNF220
Genomic location(hg19): chr1:44890310-44890442:-
Genomic location(hg38): chr1:44890310-44890442:.
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0019613
MONDO name: non-functioning pituitary adenoma
Disease details: non-functioning pituitary adenoma
Disease DO ID:
 5715
Disease MeSH ID:
 -
Disease NCIt ID:
 C4348
Disease ICD11 ID:
 1197752358
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

pituitary tumour tissues / tumour
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: hsa_circ_0069707
Associated microRNA: -
Biological function: Associated with tumour recurrence/progression and progression-free survival (PFS) in NFPA; part of a prognostic signature.
Molecular mechanism: Bioinformatics-based co-expression/functional enrichment suggests involvement in vesicle transport and cellular response to unfolded proteins; reported binding with hsa_circ_0069707.
Biological pathway or process:

other pathway/process (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis; Survival Analysis; ROC Analysis; Cohort Study
Clinical significance:

Part of a two-circRNA signature that predicts tumour recurrence/progression and stratifies PFS risk in NFPA.
Description:

hsa_circ_0000066 (RNF220-derived) is one component of a two-circRNA prognostic signature for NFPA that stratifies patients into high- and low-risk recurrence/progression groups with different PFS. Mechanistically, the study provides bioinformatics evidence suggesting co-expression-based functional links to vesicle transport and unfolded-protein response processes, and reports a predicted binding relationship with hsa_circ_0069707.
Confidence score:

0.5121
Other information
Title:

A two‑circRNA signature predicts tumour recurrence in clinical non‑functioning pituitary adenoma.

Journal: Oncology reports
Published: 2019
PubMed ID: 30542712
Study type:

clinical study; bioinformatics study
Data availability: available from the corresponding author on reasonable request
Code availability: -