circRNA basic information
circBase ID: -
Name: hsa_circ_LARP4
Synonym: Circular RNA_LARP4 / circ LARP4
Host Gene: LARP4
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008170
MONDO name: ovarian cancer
Disease details: ovarian cancer / OC
Disease DO ID:
 2394
Disease MeSH ID:
 D010051
Disease NCIt ID:
 C7431
Disease ICD11 ID:
 685124533
Disease OMIM ID:
 167000
Species: Human
Species details: Homo sapiens
Tissue specimen:

ovarian cancer tissue; adjacent normal tissue; ovarian epithelial carcinoma tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Lower circLARP4 expression is associated with advanced FIGO stage, lymph node metastases, worse DFS and OS, and may serve as a prognostic biomarker in ovarian cancer.
Molecular mechanism: -
Biological pathway or process:

metastasis (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis
Clinical significance:

Lower circLARP4 expression was associated with poor prognosis and was identified as an independent prognostic factor for ovarian cancer.
Description:

This study found that circLARP4 is significantly down-regulated in ovarian cancer tissues compared with adjacent normal tissues. Lower circLARP4 expression is associated with advanced FIGO stage, lymph node metastases, worse DFS and OS, and independent poor prognosis, suggesting circLARP4 may be a prognostic biomarker for ovarian cancer.
Confidence score:

0.4758
Other information
Title:

Circular RNA_LARP4 is lower expressed and serves as a potential biomarker of ovarian cancer prognosis.

Journal: European review for medical and pharmacological sciences
Published: 2018
PubMed ID: 30468459
Study type:

clinical study
Data availability: -
Code availability: -