circRNA basic information
circBase ID: -
Name: hsa_circ_MYC
Synonym: circMYC
Host Gene: MYC
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: exosome; cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0015459
MONDO name: nasopharyngeal carcinoma
Disease details: nasopharyngeal carcinoma
Disease DO ID:
 9261
Disease MeSH ID:
 D00007727; D000077274
Disease NCIt ID:
 C3871
Disease ICD11 ID:
 1883313543
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum; serum exosomes; circulating serum exosomes
Cell lines:

C666-1; 5-8F; CNE-1; NP69; CNE-1/RR
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: AGO1, CRY2
Associated microRNA: miR-20b-5p, let-7e-5p
Biological function: circMYC acts as an oncogene in NPC cells, promotes cell proliferation, enhances radiotherapy resistance, and its knockdown sensitizes NPC cells to irradiation.
Molecular mechanism: Bioinformatic analysis suggested a ceRNA-like mechanism in which circMYC may interact with miR-20b-5p and let-7e-5p, which target AGO1 and CRY2; FISH showed circMYC was mainly cytoplasmic.
Biological pathway or process:

proliferation (promotes); radioresistance (promotes); ceRNA regulation (other); metastasis (promotes); drug resistance (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis; Bioinformatics Analysis; Transfection; CCK8; EdU Staining; Colony Formation Assay; FISH / smFISH
Clinical significance:

High circulating exosomal circMYC is associated with tumor size, lymphatic metastasis, TNM stage, lower overall survival, lower disease-free survival, higher recurrence, higher mortality, and can differentiate radioresistant from radiosensitive NPC patients.
Description:

This study identifies circulating serum exosomal circMYC as up-regulated in NPC, especially in radioresistant NPC, and links high circMYC expression to advanced clinical features, recurrence, and poor survival. Functional experiments indicate that circMYC promotes NPC cell proliferation and radioresistance, while circMYC knockdown sensitizes resistant cells to irradiation. Mechanistically, the study suggests a cytoplasmic ceRNA-related model involving miR-20b-5p/let-7e-5p and AGO1/CRY2 based on bioinformatic prediction.
Confidence score:

0.7173
Other information
Title:

Diagnostic value of exosomal circMYC in radioresistant nasopharyngeal carcinoma.

Journal: Head & neck
Published: 2020
PubMed ID: 32945062
Study type:

combined biological and clinical study
Data availability: -
Code availability: -