circRNA basic information
circBase ID: hsa_circ_0001729
Name: hsa_circ_MCM7
Synonym: circMCM7
Host Gene: MCM7
Genomic location(hg19): chr7:99696751-99697026:-
Genomic location(hg38): chr7:100099128-100099403:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tumor tissues; matched adjacent non-tumor tissues; non-tumor liver tissue samples; liver cancer tissues; xenograft tumor tissues
Cell lines:

Huh7; HCCLM3; MHCC97-L; Hep3B; THLE-3; HepG2; SMMC-7721
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: MCM7
Associated microRNA: -
Biological function: circMCM7 promotes HCC cell proliferation, invasion, metastasis and tumor growth, while inhibiting apoptosis; circMCM7 knockdown suppresses proliferation, invasion and xenograft tumor growth and promotes apoptosis.
Molecular mechanism: circMCM7 positively regulates its host gene MCM7 expression; MCM7 overexpression partially rescues the proliferation, invasion and apoptosis phenotypes caused by circMCM7 knockdown.
Biological pathway or process:

proliferation (promotes); invasion (promotes); apoptosis (inhibits); metastasis (promotes); other pathway/process (promotes)
Detected method:
Q
M
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Microarray; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); TUNEL; Cohort Study; Survival Analysis; Bioinformatics Analysis
Clinical significance:

Elevated circMCM7 expression is correlated with poor clinical outcomes, shorter overall survival, advanced TNM stage and lymph node metastasis in HCC patients; circMCM7 may serve as a prognostic biomarker and potential therapeutic target.
Description:

circMCM7 is an up-regulated oncogenic circRNA in hepatocellular carcinoma. It promotes HCC proliferation, invasion, metastasis and xenograft tumor growth while suppressing apoptosis, at least partly by positively regulating its host gene MCM7. High circMCM7 expression is associated with advanced TNM stage, lymph node metastasis and poor overall survival, supporting its potential as a prognostic biomarker and therapeutic target.
Confidence score:

0.823
Other information
Title:

CircMCM7 Promotes Hepatocellular Carcinoma Cell Proliferation and Metastasis By Modulating MCM7 Expression.

Journal: Journal of biochemical and molecular toxicology
Published: 2026
PubMed ID: 41502012
Study type:

combined biological and clinical study
Data availability: GSE121714; The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.
Code availability: -