circRNA basic information
circBase ID: hsa_circ_0001806
Name: hsa_circ_CSPP1
Synonym: hsa_circCSPP1_041
Host Gene: CSPP1
Genomic location(hg19): chr8:68018139-68028357:+
Genomic location(hg38): chr8:67105904-67116122:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissues; matched non-cancerous tissues; serum
Cell lines:

MKN-45; SGC-7901; MKN-1; BGC-823; GES-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: target mRNAs
Associated microRNA: hsa-miR-193a-5p, hsa-miR-146a-3p, hsa-miR-374b-3p, hsa-miR-4326, hsa-miR-4427, hsa-miR-4648, hsa-miR-548av-3p, hsa-miR-6756-5p, hsa-miR-6766-5p, hsa-miR-6770-5p
Biological function: Serum circCSPP1 may serve as a diagnostic and prognostic biomarker for gastric cancer, help distinguish GC patients from healthy donors, monitor postoperative reduction and recurrence, and is associated with poor survival when highly expressed.
Molecular mechanism: circCSPP1 is mainly cytoplasmic and may participate in posttranscriptional regulation through a predicted circRNA-miRNA-mRNA ceRNA regulatory network.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

circRNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Survival Analysis; ROC Analysis; Bioinformatics Analysis
Clinical significance:

High serum circCSPP1 expression is associated with poor survival, tumor size, T stage, lymph node metastasis and TNM stage; serum circCSPP1 has diagnostic value for distinguishing GC patients from healthy donors with AUC 0.834, and combined circCSPP1, CEA and CA19-9 achieved AUC 0.882.
Description:

circCSPP1 (hsa_circ_0001806) is an exonic circRNA derived from CSPP1 and is up-regulated in gastric cancer tissues, serum, and cell lines. The study supports serum circCSPP1 as a non-invasive diagnostic, recurrence-monitoring, and prognostic biomarker for gastric cancer, with high expression associated with poor survival and advanced clinicopathological features. Mechanistically, circCSPP1 is mainly cytoplasmic and the authors predicted a circCSPP1-miRNA-mRNA ceRNA regulatory network, but downstream interactions were bioinformatically predicted rather than experimentally validated.
Confidence score:

0.7297
Other information
Title:

A comprehensive evaluation of serum circCSPP1 as a novel diagnostic and prognostic biomarker for gastric cancer.

Journal: Clinics and research in hepatology and gastroenterology
Published: 2024
PubMed ID: 38744073
Study type:

combined biological and clinical study
Data availability: The datasets generated during the current study are available from the corresponding author on reasonable request (kongshan@jspgh.com); Supplementary material associated with this article can be found, in the online version, at doi:10.1016/j.clinre.2024.102367.
Code availability: -