| Expression pattern: |
UP |
| Associated gene: |
TGF-alpha |
| Associated microRNA: |
miR-144-3p |
| Biological function: |
Promotes cisplatin resistance, enhances autophagy, increases cell viability/proliferation, inhibits apoptosis, and promotes tumor growth in thyroid carcinoma cells. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-144-3p, releasing repression of TGF-alpha and thereby activating autophagy under cisplatin treatment, leading to reduced apoptosis and increased cisplatin resistance. |
| Biological pathway or process: |
autophagy (promotes); apoptosis (inhibits); proliferation (promotes); chemoresistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; Western Blot; IF (Immunofluorescence); IHC (Immunohistochemistry); MTT; Annexin V/PI Flow Cytometry; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
This study reports that circEIF6 (hsa_circ_0060060) is upregulated in thyroid carcinoma and promotes cisplatin resistance. Mechanistically, circEIF6 sponges miR-144-3p to increase TGF-alpha expression, thereby enhancing autophagy and inhibiting apoptosis in PTC/ATC cells, and circEIF6 knockdown increases cisplatin sensitivity in a BHT101 xenograft model. |
| Confidence score: |
0.7756 |