| Expression pattern: |
DN |
| Associated gene: |
STAT3, ZEB1 |
| Associated microRNA: |
miR-21-5p |
| Biological function: |
Tumor suppressor in HNSCC; inhibits proliferation; suppresses migration and invasion; suppresses EMT |
| Molecular mechanism: |
CircRNA_ACAP2 sponges miR-21-5p and modulates STAT3 signaling (including STAT3 phosphorylation) and downstream ZEB1 to regulate EMT |
| Biological pathway or process: |
EMT (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; FISH / smFISH; Luciferase Reporter Assay; Transfection; CCK8; Wound Healing Assay; Western Blot; IHC (Immunohistochemistry); Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Higher CircRNA_ACAP2 expression (positive group) is associated with better overall survival in HNSCC patients |
| Description: |
CircRNA_ACAP2 is down-regulated in HNSCC and acts as a tumor suppressor. It primarily localizes to the cytoplasm and inhibits EMT-related behaviors (proliferation, migration/invasion) by sponging miR-21-5p to modulate STAT3 signaling and downstream ZEB1, and higher expression is associated with better overall survival. |
| Confidence score: |
0.7696 |