| Expression pattern: |
UP |
| Associated gene: |
ESCO2 |
| Associated microRNA: |
miR-374a-5p |
| Biological function: |
Promotes CRC cell proliferation, colony formation, cell-cycle progression, invasion, migration, EMT and in vivo tumorigenesis; inhibits apoptosis. |
| Molecular mechanism: |
circMETTL15 acts as a ceRNA sponge for miR-374a-5p to regulate ESCO2 expression, promoting malignant CRC cell behavior. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); apoptosis (inhibits); cell cycle (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circMETTL15 abundance was positively associated with tumor size, TNM stage, lymph node metastasis and poorer overall survival; it may be a prognostic or diagnostic biomarker in CRC. |
| Description: |
circMETTL15 is up-regulated in colorectal cancer tissues and cell lines and high expression is associated with adverse clinicopathological features and poor overall survival. Functionally, circMETTL15 promotes CRC cell proliferation, invasion, migration, EMT and tumor growth while inhibiting apoptosis. Mechanistically, it acts as a ceRNA for miR-374a-5p to increase ESCO2 expression. |
| Confidence score: |
0.8593 |