| Expression pattern: |
UP |
| Associated gene: |
FOXP4 |
| Associated microRNA: |
miR-4316 |
| Biological function: |
circMYO9B acts as an oncogenic circRNA in breast cancer, promoting BC cell proliferation, migration, invasion and in vivo tumor growth. |
| Molecular mechanism: |
circMYO9B sponges miR-4316 to relieve repression of FOXP4 and upregulate FOXP4 expression in BC cells. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Transfection; CCK8; BrdU; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
High circMYO9B expression was linked to lower overall survival rate and poor clinicopathologic features, suggesting potential prognostic biomarker value in BC. |
| Description: |
circMYO9B is up-regulated in breast cancer tissues and cell lines and high expression is associated with poor survival and adverse clinicopathologic features. Functionally, circMYO9B promotes breast cancer cell proliferation, migration, invasion and xenograft tumor growth. Mechanistically, it acts through the circMYO9B/miR-4316/FOXP4 ceRNA axis by sponging miR-4316 to increase FOXP4 expression. |
| Confidence score: |
0.7789 |